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26 有用 Riobluemoon 看过 2020-10-09 19:57:45
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看了两集，都不用“盖棺定论”，现在就可以宣布为差片了。叙事叙事无逻辑，剧情剧情一团乱，对话对话白开水. 完全没有一点点能激起人想要看下去的欲望的优点。女主的胸部实在是太大？如果真地连这个都可以作为留一丝悬念的理由，那我觉得得好好向《租借女友》道歉了。接下来用脚趾都能想到，剧情肯定向爱丽丝的过去拓展，再讲讲两国斗争，讲讲换位思考，救赎与被救赎，然后在一堆无意义堆叠的恋爱情节中结束。确实也不能期待什. 看了两集，都不用“盖棺定论”，现在就可以宣布为差片了。叙事叙事无逻辑，剧情剧情一团乱，对话对话白开水. 完全没有一点点能激起人想要看下去的欲望的优点。女主的胸部实在是太大？如果真地连这个都可以作为留一丝悬念的理由，那我觉得得好好向《租借女友》道歉了。接下来用脚趾都能想到，剧情肯定向爱丽丝的过去拓展，再讲讲两国斗争，讲讲换位思考，救赎与被救赎，然后在一堆无意义堆叠的恋爱情节中结束。确实也不能期待什么，原作没有看过，但一看动漫监督有大沼心，你还想看到有多么好的动漫？ (展开)
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
[No authors listed] [No authors listed] Blood. 2016 Dec 22;128(25):3013. doi: 10.1182/blood-2016-11-750505. Blood. 2016. PMID: 28007736 No abstract available.
Ruxolitinib is a potent Janus kinase (JAK)1/JAK2 inhibitor that has demonstrated rapid reductions in splenomegaly and marked improvement in disease-related symptoms 这12个最佳加密货币应用程序为初学者 and quality of life in patients with myelofibrosis (MF). The present analysis reports the 3-year follow-up (median, 151 weeks) of the efficacy and safety of Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II (the COMFORT-II Trial), comparing ruxolitinib with the best available therapy (BAT) in 219 patients with intermediate-2 and high-risk MF. In the ruxolitinib arm, with continued therapy, spleen volume reductions of 这12个最佳加密货币应用程序为初学者 ≥35% by magnetic resonance imaging (equivalent to approximately 50% reduction by palpation) were sustained for at 这12个最佳加密货币应用程序为初学者 least 144 weeks, with the probability of 50% (95% confidence interval [CI], 36-63) among patients achieving such degree of response. At the time of this analysis, 45% of the patients randomized to ruxolitinib remained on treatment. Ruxolitinib continues to be well tolerated. Anemia and thrombocytopenia were the main toxicities, but they were generally manageable, improved over time, and rarely led to treatment discontinuation (1% and 这12个最佳加密货币应用程序为初学者 3.6% of patients, respectively). No single nonhematologic adverse event led to definitive ruxolitinib discontinuation in more than 1 patient. Additionally, patients randomized to ruxolitinib showed longer overall survival than those randomized to BAT (hazard ratio, 0.48; 95% CI, 0.28-0.85; log-rank test, P = .009).
Trial registration: ClinicalTrials.gov NCT00934544.
Mascarenhas J, Hoffman R, Talpaz M, Gerds AT, Stein B, Gupta V, Szoke A, Drummond M, Pristupa A, Granston T, Daly R, Al-Fayoumi S, Callahan JA, Singer JW, Gotlib J, Jamieson C, Harrison C, Mesa R, Verstovsek S. Mascarenhas J, et al. JAMA Oncol. 2018 May 1;4(5):652-659. doi: 10.1001/jamaoncol.2017.5818. JAMA Oncol. 2018. PMID: 29522138 Free PMC article. Clinical Trial.
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, McQuitty M, Hunter DS, Levy R, Knoops L, Cervantes F, Vannucchi AM, Barbui T, Barosi G. Harrison C, et al. N Engl J Med. 2012 Mar 1;366(9):787-98. doi: 10.1056/NEJMoa1110556. N Engl J Med. 2012. PMID: 22375970 Clinical Trial.
Martí-Carvajal AJ, Anand V, Solà I. Martí-Carvajal AJ, et al. Cochrane Database Syst Rev. 2015 Apr 10;(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. Cochrane Database Syst Rev. 2015. PMID: 25860512 Review.
Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA, Sarlis NJ, Peng W, Sandor V, Gopalakrishna P, Hmissi A, Stalbovskaya V, Gupta V, Harrison C, Verstovsek S; COMFORT Investigators. Vannucchi AM, et al. Haematologica. 2015 Sep;100(9):1139-45. doi: 10.3324/haematol.2014.119545. Epub 2015 Jun 11. Haematologica. 2015. PMID: 26069290 Free PMC article. Clinical Trial.
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, 这12个最佳加密货币应用程序为初学者 DiPersio JF, Catalano JV, Deininger M, Miller C, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner E, Lyons RM, Paquette R, Raza A, Vaddi K, Erickson-Viitanen S, Koumenis IL, Sun W, Sandor V, Kantarjian HM. Verstovsek S, et al. N Engl J Med. 2012 这12个最佳加密货币应用程序为初学者 Mar 1;366(9):799-807. doi: 10.1056/NEJMoa1110557. N Engl J Med. 2012. PMID: 22375971 Free PMC article. Clinical Trial.
Lee SS, Verstovsek S, Pemmaraju N. Lee SS, et al. J Immunother Precis Oncol. 2021 Jun 29;4(3):117-128. doi: 10.36401/JIPO-20-35. eCollection 2021 Aug. J Immunother Precis Oncol. 2021. PMID: 35663101 Free PMC article. Review.
Salit RB. Salit RB. Bone Marrow Transplant. 2022 Jun;57(6):857-865. doi: 10.1038/s41409-022-01649-y. Epub 2022 Apr 6. Bone Marrow Transplant. 2022. PMID: 35388118 Review.
Schneider J, Jeon YW, Suh YJ, Lim ST. Schneider J, et al. Int J Mol Sci. 2022 Feb 25;23(5):2535. doi: 10.3390/ijms23052535. Int J Mol Sci. 2022. PMID: 35269680 Free PMC article.
Barosi G, Gale RP. Barosi G, et al. Blood Adv. 2022 Apr 12;6(7):2331-2333. doi: 10.1182/bloodadvances.2022007230. Blood Adv. 2022. PMID: 35240682 Free PMC article. No abstract available.
Tvorogov D, Thompson-Peach CAL, Foßelteder J, Dottore M, Stomski F, Onnesha SA, Lim K, Moretti PAB, Pitson SM, Ross DM, Reinisch A, Thomas D, Lopez AF. Tvorogov D, et 这12个最佳加密货币应用程序为初学者 al. EMBO Rep. 2022 Apr 5;23(4):e52904. doi: 10.15252/embr.202152904. Epub 2022 Feb 14. EMBO Rep. 2022. PMID: 35156745 Free PMC article.
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