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这是你与我的最后战场,或是开创世界的圣战 キミと僕の最後の戦場、あるいは世界が始まる聖戦 (2020)



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所以队长究竟是怎么当上队长的 Outsider 2021-08-29 12:16
> 全部讨论1条
讨论 作者 回应 最后回应
所以队长究竟是怎么当上队长的 Outsider 2021-08-29 12:16
> 全部讨论1条

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26 有用 Riobluemoon 看过 2020-10-09 19:57:45

10 有用 念朝夕 看过 2020-10-08 21:18:16

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看了两集,都不用“盖棺定论”,现在就可以宣布为差片了。叙事叙事无逻辑,剧情剧情一团乱,对话对话白开水. 完全没有一点点能激起人想要看下去的欲望的优点。女主的胸部实在是太大?如果真地连这个都可以作为留一丝悬念的理由,那我觉得得好好向《租借女友》道歉了。接下来用脚趾都能想到,剧情肯定向爱丽丝的过去拓展,再讲讲两国斗争,讲讲换位思考,救赎与被救赎,然后在一堆无意义堆叠的恋爱情节中结束。确实也不能期待什. 看了两集,都不用“盖棺定论”,现在就可以宣布为差片了。叙事叙事无逻辑,剧情剧情一团乱,对话对话白开水. 完全没有一点点能激起人想要看下去的欲望的优点。女主的胸部实在是太大?如果真地连这个都可以作为留一丝悬念的理由,那我觉得得好好向《租借女友》道歉了。接下来用脚趾都能想到,剧情肯定向爱丽丝的过去拓展,再讲讲两国斗争,讲讲换位思考,救赎与被救赎,然后在一堆无意义堆叠的恋爱情节中结束。确实也不能期待什么,原作没有看过,但一看动漫监督有大沼心,你还想看到有多么好的动漫? (展开)

Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis

[No authors listed] [No authors listed] Blood. 2016 Dec 22;128(25):3013. doi: 10.1182/blood-2016-11-750505. Blood. 2016. PMID: 28007736 No abstract available.


Ruxolitinib is a potent Janus kinase (JAK)1/JAK2 inhibitor that has demonstrated rapid reductions in splenomegaly and marked improvement in disease-related symptoms 这12个最佳加密货币应用程序为初学者 and quality of life in patients with myelofibrosis (MF). The present analysis reports the 3-year follow-up (median, 151 weeks) of the efficacy and safety of Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II (the COMFORT-II Trial), comparing ruxolitinib with the best available therapy (BAT) in 219 patients with intermediate-2 and high-risk MF. In the ruxolitinib arm, with continued therapy, spleen volume reductions of 这12个最佳加密货币应用程序为初学者 ≥35% by magnetic resonance imaging (equivalent to approximately 50% reduction by palpation) were sustained for at 这12个最佳加密货币应用程序为初学者 least 144 weeks, with the probability of 50% (95% confidence interval [CI], 36-63) among patients achieving such degree of response. At the time of this analysis, 45% of the patients randomized to ruxolitinib remained on treatment. Ruxolitinib continues to be well tolerated. Anemia and thrombocytopenia were the main toxicities, but they were generally manageable, improved over time, and rarely led to treatment discontinuation (1% and 这12个最佳加密货币应用程序为初学者 3.6% of patients, respectively). No single nonhematologic adverse event led to definitive ruxolitinib discontinuation in more than 1 patient. Additionally, patients randomized to ruxolitinib showed longer overall survival than those randomized to BAT (hazard ratio, 0.48; 95% CI, 0.28-0.85; log-rank test, P = .009).

Trial registration: ClinicalTrials.gov NCT00934544.

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