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2022外匯平台排名清單

通达信多周期k线

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Coordination of mitophagy and mitochondrial biogenesis 通达信多周期k线 通达信多周期k线 during ageing in C. elegans

Impaired mitochondrial maintenance in disparate cell types is a shared hallmark of many human pathologies and ageing. How mitochondrial biogenesis coordinates with the removal of damaged or 通达信多周期k线 superfluous mitochondria to maintain cellular homeostasis is not well understood. Here we show that mitophagy, a 通达信多周期k线 selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content 通达信多周期k线 通达信多周期k线 and longevity in Caenorhabditis elegans. We find that DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans. Impairment of mitophagy compromises stress resistance 通达信多周期k线 and triggers mitochondrial retrograde signalling through the SKN-1 transcription factor that regulates both mitochondrial biogenesis genes and mitophagy by enhancing DCT-1 expression. Our findings reveal a homeostatic feedback loop that integrates metabolic signals to coordinate the biogenesis and turnover of mitochondria. Uncoupling of these two processes during ageing contributes to overproliferation of damaged mitochondria and decline of cellular function.

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Palikaras K, 通达信多周期k线 Lionaki E, Tavernarakis N. Palikaras K, et al. Autophagy. 2015;11(8):1428-30. doi: 10.1080/15548627.2015.1061172. Autophagy. 2015. PMID: 26083448 Free PMC article.

Fang EF, Waltz TB, Kassahun H, 通达信多周期k线 Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG. Fang EF, et al. Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208. Sci Rep. 2017. PMID: 28397803 Free PMC article.

Princz A, Pelisch F, Tavernarakis N. Princz A, et al. Sci Rep. 2020 Sep 23;10(1):15513. doi: 10.1038/s41598-020-72637-9. Sci Rep. 2020. PMID: 32968203 Free PMC article.

Palikaras K, Tavernarakis N. Palikaras K, et al. Exp Gerontol. 2014 Aug;56:182-8. doi: 10.1016/j.exger.2014.01.021. Epub 2014 Jan 28. Exp Gerontol. 2014. PMID: 24486129 Review.

Leboutet R, Chen Y, Legouis R, Culetto E. Leboutet R, et al. Mech Ageing Dev. 2020 Jul;189:111266. doi: 10.1016/j.mad.2020.111266. Epub 通达信多周期k线 2020 May 23. Mech Ageing Dev. 2020. PMID: 32454052 Review.

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Fernandez AM, Martinez-Rachadell L, Navarrete M, Pose-Utrilla J, Davila JC, Pignatelli J, Diaz-Pacheco S, Guerra-Cantera S, Viedma-Moreno E, Palenzuela R, Ruiz de Martin Esteban S, Mostany R, Garcia-Caceres C, Tschöp M, Iglesias T, de Ceballos ML, Gutierrez A, Torres Aleman I. Fernandez AM, et al. Proc Natl Acad Sci U 通达信多周期k线 S A. 2022 Jul 19;119(29):e2204527119. doi: 10.1073/pnas.2204527119. Epub 2022 Jul 14. Proc Natl Acad Sci U S A. 2022. PMID: 35858325

Yan Y, Tang J, Yuan Q, Liu C, Chen X, Liu H, Huang J, Bao C, Hsiang T, Zheng L. Yan Y, et al. Commun Biol. 2022 Jul 14;5(1):698. doi: 10.1038/s42003-022-03666-5. Commun Biol. 2022. PMID: 35835849 Free PMC article.

Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T. Naranjo-Galindo 通达信多周期k线 FJ, et al. Front Aging. 2022 Jun 22;3:916118. doi: 10.3389/fragi.2022.916118. eCollection 通达信多周期k线 2022. Front Aging. 2022. PMID: 35821838 Free PMC article. Review.

Vega M, Castillo D, de Cubas L, Wang Y, Huang Y, Hidalgo E, Cabrera M. Vega M, et al. BMC Biol. 2022 Jul 12;20(1):160. doi: 10.1186/s12915-022-01352-w. BMC Biol. 2022. PMID: 35820914 Free PMC article.

Li J, Wang Z, Li C, Song Y, Wang Y, Bo H, Zhang 通达信多周期k线 Y. Li J, et al. Cells. 2022 Jun 30;11(13):2086. doi: 10.3390/cells11132086. Cells. 2022. PMID: 35805170 Free PMC article. Review.

Mitochondrial disorders as windows into an ancient organelle

Much of our current knowledge about mitochondria has come from studying patients who have respiratory chain disorders. These disorders comprise a large collection of individually rare syndromes, each presenting in a unique and often devastating way. In recent years, there has been great progress in defining their genetic basis, but we still know little about the cascade of events that gives rise to such diverse pathology. Here, we review these disorders and explore them in the context of a contemporary understanding of mitochondrial evolution, biochemistry and genetics. Fully deciphering their pathogenesis is a challenging next step that will inspire the development of drug treatments for rare and common diseases.

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Liu 通达信多周期k线 SJ, Zhang YP. Liu SJ, et al. Curr Mol Med. 2014;14(10):1245-6. doi: 10.2174/1566524014666141202125126. Curr Mol Med. 2014. PMID: 25470294 No abstract available.

Almannai M, El-Hattab AW, Ali M, Soler-Alfonso C, Scaglia F. Almannai M, et al. Mol Genet Metab. 2020 Sep-Oct;131(1-2):通达信多周期k线 通达信多周期k线 通达信多周期k线 1-13. doi: 10.1016/j.ymgme.2020.10.002. Epub 2020 Oct 6. Mol Genet Metab. 2020. PMID: 33129691 Free PMC article. Review.

Doccini S, Meschini MC, Mei D, Guerrini R, Sicca 通达信多周期k线 F, Santorelli FM. Doccini S, et al. Neurol Sci. 2015 Nov;36(11):2151-5. doi: 10.通达信多周期k线 通达信多周期k线 1007/s10072-015-2324-9. Epub 2015 Jul 14. Neurol Sci. 2015. PMID: 26169758 No abstract available.

Scaglia F. Scaglia F. Methods Mol Biol. 2012;837:17-34. doi: 10.1007/978-1-61779-504-6_2. Methods Mol Biol. 2012. PMID: 22215538 Review.

Schon EA, DiMauro S. Schon EA, et al. Curr Med Chem. 2003 Dec;10(23):2523-33. doi: 10.2174/0929867033456503. Curr Med Chem. 2003. PMID: 14529468 Review.

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Sabharwal A, Campbell JM, Schwab TL, WareJoncas Z, Wishman MD, Ata H, Liu W, Ichino N, Hunter DE, Bergren JD, Urban MD, Urban RM, Holmberg SR, Kar B, Cook A, Ding Y, Xu 通达信多周期k线 X, Clark KJ, Ekker SC. Sabharwal A, et al. Genes (Basel). 2022 Jul 23;13(8):1317. doi: 10.3390/genes13081317. Genes (Basel). 2022. PMID: 35893052 Free PMC article.

Cameron SJ, Sheng J, Hosseinian F, Willmore WG. Cameron SJ, et al. Int J Mol Sci. 2022 Jul 19;23(14):7962. doi: 10.3390/ijms23147962. Int J Mol Sci. 2022. PMID: 35887304 Free PMC article. Review.

Abad-Jiménez Z, Vezza T, López-Domènech S, Fernández-Reyes M, Canet F, Morillas C, Gómez-Abril SÁ, Bañuls C, Víctor VM, Rocha M. Abad-Jiménez Z, et al. Antioxidants (Basel). 2022 Jun 29;11(通达信多周期k线 通达信多周期k线 7):1302. doi: 10.3390/antiox11071302. Antioxidants (Basel). 2022. PMID: 35883794 Free PMC article.

Kiyama T, Chen 通达信多周期k线 CK, Zhang A, Mao CA. Kiyama T, et al. Cells. 2022 Jul 14;11(14):2203. doi: 10.3390/cells11142203. Cells. 2022. PMID: 35883647 Free PMC article.

Rodríguez-Nuevo A, Torres-Sanchez A, Duran JM, De Guirior C, Martínez-Zamora MA, Böke E. Rodríguez-Nuevo A, et al. Nature. 2022 Jul;607(7920):756-761. doi: 10.1038/s41586-022-04979-5. Epub 2022 Jul 20. Nature. 2022. PMID: 35859172 Free PMC 通达信多周期k线 article.

SPRING/SUMMER 2022

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